1,4-Dioxane

A six-membered saturated ring containing two ether oxygens.

Formula
C4H8O2
Molar mass
88.11 g/mol
Also known as
Dioxane, p-Dioxane, Diethylene ether, 1,4-Diethylene dioxide, 1,4-Dioxacyclohexane, Dioxan

Overview

A six-membered saturated ring containing two ether oxygens.

The oxygens occupy opposite positions in the ring and neither carries hydrogen. They provide hydrogen-bond acceptor sites without alcohol or phenol donor groups. The structure is a cyclic diether, not a diol.

Identifiers

Formula
C4H8O2
Molar mass
88.11 g/mol
Also known as
Dioxane, p-Dioxane, Diethylene ether, 1,4-Diethylene dioxide, 1,4-Dioxacyclohexane, Dioxan
Chemical identifiers
SMILES
C1COCCO1
InChI
InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
PubChem CID
31275

Properties

Melting Point
11.75 °C
Boiling Point
101.2 °C
Density
1.0337 g/cu cm at 20 °C
Water solubility
In water, >800 g/L at 25 °C

Related compounds

  • Ethers

    1,4-Dioxane is a specific member of the ethers family.

References

  1. PubChem Compound Summary: 1,4-Dioxane (CID 31275)National Center for Biotechnology Information · PubChem

    Identity, molecular formula, molecular weight and aliases retrieved via PUG REST on 2026-09-08.

  2. OpenStax Organic Chemistry: Names and properties of ethersJohn McMurry · OpenStax · 2023

    Supports the qualitative structure and reactivity context; identity and numerical measurements retain their original references.

  3. Hazardous Substances Data Bank (HSDB): 1,4-Dioxane — melting pointHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/31275#section=Melting-Point. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-228

  4. Hazardous Substances Data Bank (HSDB): 1,4-Dioxane — boiling pointHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/31275#section=Boiling-Point. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-228

  5. Hazardous Substances Data Bank (HSDB): 1,4-Dioxane — densityHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/31275#section=Density. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 95th Edition. CRC Press LLC, Boca Raton: FL 2014-2015, p. 3-228

  6. Hazardous Substances Data Bank (HSDB): 1,4-Dioxane — solubilityHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/31275#section=Solubility. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 118