Grignard reagents
In this scoped map, chloroalkanes, bromoalkanes and iodoalkanes can form Grignard reagents with magnesium in dry ether, extending the route map into alcohol and carboxylic acid synthesis.
- Functional group
- C-MgX
- Also known as
- organomagnesium halide, Grignard reagent
Overview
Organomagnesium halides used for carbon-carbon bond formation.
In this scoped map, chloroalkanes, bromoalkanes and iodoalkanes can form Grignard reagents with magnesium in dry ether, extending the route map into alcohol and carboxylic acid synthesis.
Identifiers
- Functional group
- C-MgX
- Also known as
- organomagnesium halide, Grignard reagent
Connected reactions
- Grignard formation: Chloroalkanes → Grignard reagents
Chloroalkanes can react with magnesium in dry ether to form Grignard reagents.
- Grignard formation: Bromoalkanes → Grignard reagents
Bromoalkanes can react with magnesium in dry ether to form Grignard reagents.
- Grignard formation: Iodoalkanes → Grignard reagents
Iodoalkanes can react with magnesium in dry ether to form Grignard reagents.
- Carbonyl addition: Grignard reagents → Primary alcohols
Grignard addition to methanal gives primary alcohols after work-up.
- Carbonyl addition: Grignard reagents → Secondary alcohols
Grignard addition to aldehydes gives secondary alcohols after work-up.
- Carbonyl addition: Grignard reagents → Tertiary alcohols
Grignard addition to ketones gives tertiary alcohols after work-up.
- Carboxylation: Grignard reagents → Carboxylic acids
Grignard carboxylation gives carboxylic acids after acidic work-up.