乙酰苯胺

苯胺经乙酰化形成的 N-苯基酰胺。

化学式
C8H9NO
官能团
N-取代酰胺
摩尔质量
135.16 g/mol
Also known as
N-phenylacetamide, Antifebrin, N-Acetylaniline, Acetanilid, Acetamidobenzene, Acetanil

概览

Its nitrogen is bonded to both phenyl and acetyl groups. Delocalisation into the carbonyl makes the nitrogen less available for protonation than in aniline. The remaining N–H bond distinguishes acetanilide from an N,N-disubstituted amide.

Identifiers

化学式
C8H9NO
官能团
N-取代酰胺
摩尔质量
135.16 g/mol
Also known as
N-phenylacetamide, Antifebrin, N-Acetylaniline, Acetanilid, Acetamidobenzene, Acetanil
化学标识符
SMILES
CC(=O)NC1=CC=CC=C1
InChI
InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
PubChem CID
904

性质

熔点
114.3 °C
沸点
304 °C @ 760 MM HG
水中溶解度
Water solubility= 6.93X10+3 mg/l at 25 °C
数据收录情况

Not published: Density.

Related compounds

Connected reactions

  • N acetylation: Aniline → Acetanilide

    苯胺的氮进攻酸酐羰基，排出乙酸根来源的离去基团。质子转移形成乙酰苯胺和乙酸；产物中的氮与 C=O 相连，成为酰胺氮。

参考文献

  1. PubChem Compound Summary: Acetanilide (CID 904)National Center for Biotechnology Information · PubChem

    Identity, molecular formula, molecular weight and aliases retrieved via PUG REST on 2026-09-08.

  2. OpenStax Organic Chemistry: Chemistry of amidesJohn McMurry · OpenStax · 2023

    Supports the qualitative structural interpretation of the recorded molecular structure; no new physical measurement or verified preparative yield is claimed.

  3. OpenStax Organic Chemistry: Reactions of aminesJohn McMurry · OpenStax · 2023

    Supports the qualitative structure and reactivity context; identity and numerical measurements retain their original references.

  4. Hazardous Substances Data Bank (HSDB): Acetanilide — melting pointHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/904#section=Melting-Point. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 76th ed. Boca Raton, FL: CRC Press Inc., 1995-1996., p. 3-5

  5. Hazardous Substances Data Bank (HSDB): Acetanilide — boiling pointHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/904#section=Boiling-Point. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 76th ed. Boca Raton, FL: CRC Press Inc., 1995-1996., p. 3-5

  6. Hazardous Substances Data Bank (HSDB): Acetanilide — solubilityHazardous Substances Data Bank (HSDB)

    Retrieved through PubChem PUG View on 2026-09-08. https://pubchem.ncbi.nlm.nih.gov/compound/904#section=Solubility. Source value, complete property clause or compact miscibility statement retained; absent pressure, temperature or phase conditions are not inferred. Original reference: Yalkowsky SH, Dannenfelser RM; The Aquasol Database of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ AZ, College of Pharmacy, PC Ver. (1992)