N acetylation
苯胺 → 乙酰苯胺：查看反应物、产物、反应条件与来源依据，探索相关转化和合成路径。
- 试剂
- 乙酸酐
- 条件
- 胺的受控酰化
- 反应类别
- N-乙酰化
- 方程式
- C6H5NH2 + CH3COOCOCH3 -> C6H5NHCOCH3 + CH3COOH
概览
苯胺的氮进攻酸酐羰基，排出乙酸根来源的离去基团。质子转移形成乙酰苯胺和乙酸；产物中的氮与 C=O 相连，成为酰胺氮。
转化
- 方程式
- C6H5NH2 + CH3COOCOCH3 -> C6H5NHCOCH3 + CH3COOH
- 反应物
- Aniline + Acetic anhydride
- 产物
- Acetanilide + Ethanoic acid
- 试剂
- 乙酸酐
- 反应环境
- 胺的受控酰化
- 反应类别
- N-乙酰化
- 机理
- nucleophilic addition-elimination
- Evidence level
- source-backed molecular example
底物范围
- 适用范围
- Aniline nitrogen receives an acetyl group.
- 来源说明
- The product is an amide; its nitrogen no longer has ordinary aniline basicity.
相关反应
- Nitro reduction and basification: Nitrobenzene → Aniline
硝基苯的硝基经还原，再进行碱化处理，生成苯胺。
参考文献
- Organic Chemistry: Chemistry of Acid AnhydridesJohn McMurry · OpenStax Organic Chemistry · 2023
Supports functional-group chemistry used to curate the linked examples. Checked 2026-09-16; named examples are applications of textbook scope, without claimed experimental yields.